Extraction Bioactive Compound of Pegagan (Centella Asiatica L.) using Solvent-Free Microwave-Assisted Extraction

Abstract Gotu Kola (Centella asiatica L.), known as pegagan is a plant with many benefits, including used to repair burns, hypertrophic wound healing, and an inflammatory agent. C. grows in tropical Asia various countries such Indonesia, Philippines, China, India, Sri Lanka, Madagascar. has four bioactive components, namely asiatic acid, asiaticoside, madecassic madecassoside. Microwave-Assisted Extraction (MAE) one of the methods for extracting compounds leaf. In this study, extraction carried out using Solvent-Free (SFME) method. This research box-behnken design model optimization process. The variables are mass material (20, 40, 60 g), power (150, 300, 450 W), time (30, 60, 90 min). highest yield 4,5474% at watt microwave power, 20 g leaves, min time. Mass factor that significant effect on yield. Modelling from appropriate which lack-of-fit > 0,1, R 2 89,67%. content by analyzing total phenolic product. most substantial phenol 2398,649 μgAGE/ml.